PRIALT is a prescription medication that is given directly into the spinal fluid. The spine is where the major nerves that carry pain sensations are located. A special device injects PRIALT into the spinal column near these nerves.

PRIALT is used to treat severe chronic pain in adults who cannot take other treatments or when other treatments have not worked.¹ Other treatments include systemic pain medicines, treatments used in combination with pain medicines, or morphine injected into the spinal fluid.

PRIALT is not a narcotic¹

• It works in a different way

PRIALT has a defined safety profile¹

• Risks and side effects have been evaluated in over 1200 patients
• If you experience side effects, PRIALT may be stopped abruptly without withdrawal effects
• Duration of treatment has ranged from a one-hour IT infusion to treatment lasting more than 7.5 years

PRIALT has been studied in multiple clinical trials¹

• Clinical trials included patients with many types of severe chronic pain

PRIALT has real-world experience¹

• It has been approved by the FDA and on the market since 2004

What is the most important safety information I should know about PRIALT?

• You should not receive PRIALT if you have or had a mental condition called psychosis
• You or a caregiver should call your doctor right away if you:
  • Are confused
  • Are less alert
  • See or feel things that are not real (hallucinations)
  • Have changes in mood or consciousness
• If you have mental symptoms or neurological problems, PRIALT treatment can be interrupted or stopped suddenly without experiencing withdrawal effects

Please see accompanying full prescribing information including boxed WARNING and important safety information

Reference: 1. PRIALT^® (ziconotide intrathecal infusion) Prescribing Information.