Non-opioid PRIALT is different¹

PRIALT is a different type of calcium channel blocker. Results in animal model studies suggest that PRIALT exerts its antinociceptive effect(s) by selectively blocking the presynaptic N-type calcium channels and reducing the release of excitatory neurotransmitters from the primary afferent nerve terminals. The mechanism of action has not been established in humans; however, this unique mechanism of action gives physicians a different option when treating severe chronic pain.

PRIALT does not bind to opioid receptors PRIALT does not potentiate opiate-induced respiratory depression Because PRIALT is not an opiate, it cannot prevent or relieve the symptoms associated with opiate withdrawal.

Please see accompanying full prescribing information including boxed WARNING and important safety information.

Reference: 1. PRIALT^® (ziconotide intrathecal infusion) Prescribing Information.